Sclerostin and Dickkopf-1 in Renal Osteodystrophy
نویسندگان
چکیده
منابع مشابه
Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU)
Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1. Subjects and Methods. We measured serum sclerostin and...
متن کاملRenal osteodystrophy.
The incidence of chronic renal disease is increasing, and the pattern of renal osteodystrophy seems to be shifting from the classic hyperparathyroid presentation to one of low bone turnover. Patients with persistent disease also live longer than previously and are more physically active. Thus, patients may experience trauma as a direct result of increased physical activity in a setting of weake...
متن کامل[Renal osteodystrophy and secondary hyperparathyroidism].
High-turnover bone due to excess PTH is one of the main types of renal osteodystrophy. In addition to the classic stimuli of PTH secretion such as hypocalcemia and decreased production of active vitamin D, new mechanisms has been suggested. Furthermore, skeletal resistance to PTH, a classic stimulus of PTH secretion in uremia, has been recently revisited as an underlying abnormality.
متن کاملSlipped epiphyses in renal osteodystrophy.
Clinical, biochemical, roentgenological, and histological features of slipped epiphyses (epiphysiolysis) in 11 out of 112 children with renal osteodystrophy have been analysed. Characteristic age-related patterns of involvement of different epiphyses are described. Quantitative measurements of iliac bone histology, serum parathyroid hormone levels, and clinical history show the presence of more...
متن کاملNew concepts in renal osteodystrophy.
number, and an increase in the number of osteoclastic Introduction resorption bays demonstrating the increased rates of bone resorption in osteitis fibrosa. Renal osteodystrophy is the term used to describe the In addition, osteitis fibrosa is characterized by a skeletal complications of end-stage renal disease. It is prominent accumulation of fibroblastic cells around a multifactorial disorder...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2010
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.06550810